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I was taking Amaryl once a day and metformin twice a day, plus Diovan for blood pressure. Use of metformin and rosiglitazone can increase the risk of serious side effects in these patients. After initiation of rosiglitazone maleate/metformin hydrochloride, and after dose increases, observe patients carefully for signs and symptoms of heart failure (including excessive, rapid weight gain, dyspnea, and/or edema). , x-rays, CT scans, and MRIs) that use intravenous contrast media—Use of metformin and rosiglitazone should be discontinued before you have one of these procedures. Published clinical information exists for the use of other sulfonylureas including glyburide, glipizide, chlorpropamide, and tolbutamide in combination with metformin.

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